Stem Cells & Bioprinting Synthetic Organs


Embryonic Stem Cells

 

As their name suggests, embryonic stem cells come from living, human embryos. They are harvested from two sources.

Embryos—Embryonic stem cells are obtained by harvesting living embryos which are generally 5-7 days old. The removal of embryonic stem cells invariably results in the destruction of the embryo.

Fetuses—Another kind of stem cell called an embryonic germ cell can be obtained from either miscarriages or aborted fetuses.

 

Embryonic stem cells are stem cells that are derived from embryos. In the practical sense, those used for research are obtained from eggs that have been in vitro fertilized (in a test tube) and ear-marked specifically for research use. Typically this is done using accepted informed consent procedures. Despite what some may suggest, they are not derived from eggs that have been fertilized in the conventional manner. The embyros that provide the embryonic stem cells are usually about 4-5 days old and are a hollow ball of cells

 

Adult Stem Cells

 

 

The primary role of adult stem cells in humans is to maintain and repair the tissue in which they are found. While we call them adult stem cells, they are more accurately called somatic (from the Greek word soma = body) stem cells, because they come from not only adults, but other sources.

Adult type stem cells come from:

Umbilical Cords, Placentas and Amniotic Fluid—Adult type stem cells can be derived from various pregnancy-related tissues.

Adult Tissues—In adults, stem cells are present within various tissues and organ systems. These include the bone marrow, liver, epidermis, retina, skeletal muscle, intestine, brain, dental pulp, and elsewhere. Even fat obtained from liposuction has been shown to contain significant numbers of adult type stem cells.

 

Cadavers—Neural stem cells have been removed from specific areas in post-mortem human brains as late as 20 hours following death.

Stem Cells from Adult Tissue or Umbilical Cord Blood.

Stem cells obtained from adult organisms are also the focus of research. There have been a number of recent publications on adult stem cells from a variety of different sources, such as bone marrow and the umbilical cord following birth.

 

Stem Cell

Stem cells are seen by many researchers as having virtually unlimited application in the treatment and cure of many human diseases and disorders including Alzheimer's, diabetes, cancer, strokes, etc. Stem cells come in two general types:

            -Embryonic stem cells are a primitive type of cell that can be coaxed into developing into all of the 220 types of cells found in the human body (e.g. blood cells, heart cells, brain cells, nerve cells, etc). They are derived from human embryos in a process that causes the death of the embryos.

            -Adult stem cells bear some similarities to embryonic stem cells. Research using adult cells has a two decade head start on embryonic stem cells. Thus, potential treatments have already advanced to human trial stage. Unfortunately, adult cells are limited in flexibility.

Adult Stem Cells

 The primary role of adult stem cells in humans is to maintain and repair the tissue in which they are found. While we call them adult stem cells, they are more accurately called somatic (from the Greek word soma = body) stem cells, because they come from not only adults, but other sources.

Adult type stem cells come from:

Umbilical Cords, Placentas and Amniotic Fluid—Adult type stem cells can be derived from various pregnancy-related tissues.

Adult Tissues—In adults, stem cells are present within various tissues and organ systems. These include the bone marrow, liver, epidermis, retina, skeletal muscle, intestine, brain, dental pulp, and elsewhere. Even fat obtained from liposuction has been shown to contain significant numbers of adult type stem cells.

 

Cadavers—Neural stem cells have been removed from specific areas in post-mortem human brains as late as 20 hours following death.

Stem Cells from Adult Tissue or Umbilical Cord Blood.

Stem cells obtained from adult organisms are also the focus of research. There have been a number of recent publications on adult stem cells from a variety of different sources, such as bone marrow and the umbilical cord following birth.

 

 Stem Cell Transplantation

 

"Stem cell transplantation, performed as support for high-dose chemotherapy, is a treatment option for many patients with myeloma. Studies have shown that this treatment improves both the response rate and survival in myeloma over that obtained with conventional chemotherapy."

"The Center for International Blood and Marrow Transplant Research (CIBMTR) estimates that approximately 4,700 stem cell transplants of various types were performed in patients with myeloma in North America in 2003 (CIBMTR, 2005)."